Warning: error_log(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/bdurrell/public_html/assetise.com/error/error.php on line 115 Warning: error_log(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/bdurrell/public_html/assetise.com/error/error.php on line 115 Warning: error_log(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/bdurrell/public_html/assetise.com/error/error.php on line 115 Warning: error_log(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/bdurrell/public_html/assetise.com/error/error.php on line 115 Warning: error_log(): It is not safe to rely on the system's timezone settings. You are *required* to use the date.timezone setting or the date_default_timezone_set() function. In case you used any of those methods and you are still getting this warning, you most likely misspelled the timezone identifier. We selected the timezone 'UTC' for now, but please set date.timezone to select your timezone. in /home/bdurrell/public_html/assetise.com/error/error.php on line 115 [Noah's Classifieds] - CJ-023423 (CAS 415903-37-6) - LS-H7180 Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and res
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Created 2019-07-04
Owner freemexy
Title CJ-023423 (CAS 415903-37-6) - LS-H7180 Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and res
Description CJ-023423 (CAS 415903-37-6) - LS-H7180 Prostaglandin E2 (PGE2 ) activates four E prostanoid (EP) receptors, EP1-4 . EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. 415903-37-6 is a potent and selective antagonist of the EP4 receptor (Ki = 13 and 20 nM for human and rat EP4, respectively). It inhibits PGE2 -evoked elevation in intracellular cAMP in cells and, in vivo, reduces thermal hyperalgesia induced by intraplantar injection of PGE2 . CJ-023423 reduces acute and chronic inflammatory pain in different mouse models. CJ-023423 is supplied as a crystalline solid. A stock solution may be made by dissolving the CJ-023423 in the solvent of choice. CJ-023423 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of CJ-023423 is approximately 10 mg/ml in ethanol and DMSO and approximately 20 mg/ml in DMF. CJ-023423 is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, CJ-023423 should first be dissolved in DMF and then diluted with the aqueous buffer of choice. CJ-023423 has a solubility of approximately 0.25 mg/ml in a 1:3 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
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