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Created 2019-10-07
Owner freemexy
Title Nootropics Dihexa Powder CAS
Description Nootropics Dihexa Powder CAS Catalogue number: H293745 Chemical name: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) Synonyms: N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide CAS Number: 1401708-83-5 Structure: Nootropics Dihexa Withcas: 1401708-83-5 Molecular form.: CHNO Appearance: White Solid Melting Point: >209°C (dec.) Mol. Weight: 504.66 Storage: Hygroscopic, Refrigerator, under inert atmosphere Solubility: DMSO (Slightly), Methanol (Slightly) Stability: No Data Available Category: No Data Available Boiling Point: No Data Available Applications: N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent. References: McCoy, A., et al.: J. Pharm. Exp. Ther., 344, 141 (2013) Dihexa powder, also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models ofAlzheimer's disease-like mental impairment. In an assay of neurotrophicactivity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. According to a patent, "Short duration safety studies with Dihexa have uncovered no apparenttoxicity. Of particular note is a lack of neoplastic induction, since c-Met is recognized as anoncogene. This is unsurprising since oncogenesis requires multiple mutations including both oncogene induction and tumor suppressor attenuation.
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